In 1947, he joined Pierre Schaeffer's Club d'Essai on RTF (Radio Télévision Française) as a radio producer. During the 1950s, he produced many radio plays based on French writers, with a preference for Surrealists like André Breton, René Char, Jean Cocteau, Antonin Artaud, Julien Gracq
Almuró used increasingly difficult and provocative texts for his radio plays, like Jean Genet's homoerotic poem Le Condamné à Mort, for which Almuró created electroacoustic music in 1952, or Antonin Artaud's Van Gogh, Le Suicidé De La Société in 1958, a text written 1947, the same year as Pour en Finir avec le Jugement de Dieu [To Have Done With the Judgment of God], written for radio but withheld from broadcast by directors in 1948.
In 1957, his meeting with 15-year-old Pierre Clémenti influenced Almuró to start recording Clémenti's poetry readings and make him his assistant. Clémenti, born 1942, later became actor and film director, collaborating with Almuró on several films.
When Schaeffer founded his Groupe de Recherches Musicales in 1958, Almuró joined as a member for several years, but soon launched his own, independent recording studio in the early 1960s. Here he produced incidental music and collaborations with other artists, like singer Colette Magny, with whom he published two LPs, Avec, 1966 and Bura Bura, 1967.
In 1973, Almuró became a teacher at Paris' Sorbonne University (UFR d’Arts Plastiques, Faculté Paris I Sorbonne). Other teachers included writer Dominique Noguez and contemporary artist Michel Journiac. Students included film maker Stéphane Marti and musicians Jean-Luc Guionnet and Eric Cordier.
In 1976, he created a live performance titled Partition with French contemporary artist Ange Leccia, and founded the Son-Images-Corps performance group with students. His opera Close Up was premiered in Poitiers, France.
In 1978 he directed his first film, Cortège, with music by electroacoustic music composer and Almuró student, Philippe Jubard. Almuró's cinema is overtly homoerotic and has been described as "un cinéma d’orgasme et de désir entre deux hommes" (pleasure and desire between two men) by French film director Christian Lebrat. From this date, Almuró directed more than 30 films, including Alliage, 1985, Point Vélique, 1986 and Corps Intérieur, 1988